A PRACTICAL METHOD OF PROPHYLACTIC IMMUNIZATION AGAINST TUBERCULOSIS
نویسندگان
چکیده
منابع مشابه
Prophylactic Immunization against Streptococcus sanguis.
Streptococcus sanguis (the Streptococcus s.b.e. of Loewe), originally identified by White and his coworkers, has, with few exceptions, been isolated only from the blood stream of patients with subacute bacterial endocarditis (White, 1944; White and Niven, 1946; Niven and White, 1946; Loewe et al., 1946; Niven et al., 1946; Washburn et al., 1946). This causative organism has a type specificity a...
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BACKGROUND BCG, the only licensed vaccine against tuberculosis, provides some protection against disseminated disease in infants but has little effect on prevention of adult pulmonary disease. Newer parenteral immunization prime boost regimes may provide improved protection in experimental animal models but are unproven in man so that there remains a need for new and improved immunization strat...
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The isolation and cultivation of the tubercle bacillus by R. Kocli gave a great impetus to the efforts to immunize susceptible animals against tuberculosis. The methods of vaccination successfully used in a certain number of bacterial infections were naturally seized upon so as to arrive at the same results in this disease. The discovery of tuberculin by Koch led people to hope that it would be...
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Objective(s): Mycobacterium tuberculosis (M. tuberculosis), an intracellular pathogen, causes 1.5 million deaths globally. Bacilli Calmette-Guérin (BCG) is commonly administered to protect people against M. tuberculosis infection; however, there are some obstacles with this first-generation vaccine. DNA vaccines, the third generation vaccines, can induce cellular immun...
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OBJECTIVE Mycobacterium tuberculosis infection is a major global threat to human health. The only tuberculosis (TB) vaccine currently available is bacillus Calmette-Guérin (BCG), although it has no efficacy in adults. Therefore, the development of a novel vaccine against TB for adults is desired. METHOD A novel TB vaccine expressing mycobacterial heat shock protein 65 (HSP65) and interleukin-...
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ژورنال
عنوان ژورنال: Journal of the American Medical Association
سال: 1912
ISSN: 0002-9955
DOI: 10.1001/jama.1912.04260050180007